Article
Development of an unbiased statistical method for the analysis of unigenic evolution.
BMC bioinformatics - 17 Mar 2006
Behrsin Colleen D, Brandl Chris J, Litchfield David W, Shilton Brian H, Wahl Lindi M
Abstract excerpt
BACKGROUND: Unigenic evolution is a powerful genetic strategy involving random mutagenesis of a single gene product to delineate functionally important domains of a protein. This method involves selection of variants of the protein which retain function, followed by statistical analysis comparing expected and observed mutation frequencies of each residue. Resultant mutability indices for each residue are averaged...
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