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Article

Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro.

Oncogene - 15 Aug 2002

Lakka Sajani S, Jasti Sushma L, Gondi Christopher, Boyd Douglas, Chandrasekar Nirmala, Dinh Dzung H, Olivero William C, Gujrati Meena, Rao Jasti S

Abstract excerpt

We previously showed that enhanced expression of MMP-9, an endopeptidase that digests basement-membrane type IV collagen, is related to tumor progression in vitro and in vivo; antisense-MMP-9 stably transfected clones were less invasive than untransfected parental cells and did not form tumors in nude mice. In this study, we examined the role of ERK-1 in the regulation of MMP-9 production and the invasive...

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PMID: 12165859
DOI: 10.1038/sj.onc.1205646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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