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Article

Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin.

Journal of cellular biochemistry - 1 Sept 2011

Zuo Jian-Hong, Zhu Wei, Li Mao-Yu, Li Xin-Hui, Yi Hong, Zeng Gu-Qing, Wan Xun-Xun, He Qiu-Yan, Li Jian-Huang, Qu Jia-Quan, Chen Yu, Xiao Zhi-Qiang

Abstract excerpt

EGFR is a potent stimulator of invasion and metastasis in head and neck squamous cell carcinomas (HNSCC). However, the mechanism by which EGFR may stimulate tumor cell invasion and metastasis still need to be elucidated. In this study, we showed that activation of EGFR by EGF in HNSCC cell line SCC10A enhanced cell migration and invasion, and induced loss of epitheloid phenotype in parallel with downregulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21557297
DOI: 10.1002/jcb.23175

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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