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Strong Activation of p53 by Actinomycin D and Nutlin-3a Overcomes Resistance of Cancer Cells to the Pro-apoptotic Activity of FAS Ligand

2024-04-18

Abstract excerpt

The FAS ligand (FASLG) is expressed on lymphocytes, which employ it to activated death receptors on targets cells. Cancer cells are generally resistant to apoptosis triggered by FASLG. In this work we found a way to circumvent this resistance by treatment with actinomycin D (ActD) and nutlin-3a (Nut3a). We selected this drug combination based on our transcriptomic data showing strong activation of proapoptotic gen...

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Identifiers and source

Literature Corpus work
32e6d5f0-4a82-50a8-abb9-4502842e3150
DOI
10.20944/preprints202310.1608.v2
Open publication

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Strong Activation of p53 by Actinomycin D and Nutlin-3a Overcomes Resistance of Cancer Cells to the Pro-apoptotic Activity of FAS LigandDOI 10.20944/preprints202310.1608.v2
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