Article
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.
Molecular cell - 1 Feb 1998
Xu Q, Reed J C
Abstract excerpt
The mammalian proapoptotic protein Bax confers a lethal phenotype when expressed in yeast. By exploiting this phenotype, we have identified a novel human Bax inhibitor, BI-1. BI-1 is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments and is predom...
Topics
- Animals
- Antineoplastic Agents, Phytogenic
- Apoptosis
- Apoptosis Regulatory Proteins
- COS Cells
- Carcinogens
- DNA, Antisense
- DNA, Complementary
- Etoposide
- Fibroblasts
- Gene Expression Regulation, Fungal
- Gene Library
- Genetic Testing
- Growth Substances
- Humans
- Intracellular Membranes
- Mammals
- Membrane Proteins