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Article

Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity.

The Journal of biological chemistry - 4 Jan 2008

Zhou Dujin, Shen Ruoqing, Ye Jing Jing, Li Yuping, Tsark Walter, Isbell Donna, Tso Patrick, Chen Shiuan

Abstract excerpt

PNRC2 was identified in our laboratory as a general cofactor for nuclear receptors. To better characterize the physiological function of PNRC2, we used gene-targeting technology to generate PNRC2-null mice (PNRC2(-/-) mice). These PNRC2(-/-) mice are viable and fertile. PNRC2-null mice, especially male mice, are lean and are resistant to high fat diet-induced obesity but without the induction of insulin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17971453
DOI: 10.1074/jbc.M703234200

Genes

PNRC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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