Article
Role of H(abc) domain in membrane trafficking and targeting of syntaxin 1A.
Biochemical and biophysical research communications - 27 Jul 2007
Fan Junmei, Yang Xiaofei, Lu Jingze, Chen Liangyi, Xu Pingyong
Abstract excerpt
Membrane syntaxin plays essential roles in exocytosis in eukaryotic cells. The conservative H(abc) domain in plasma membrane syntaxins implies important roles for syntaxin targeting and function. Our previous study showed H(abc) domain was necessary for the trafficking and cluster distribution of syntaxin 1A on the plasma membrane. Here we identified which of the three domains (H(a), H(b) and H(c)) was essential...
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