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Article

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

Nature cell biology - 1 May 2003

Sasaki Atsuo, Taketomi Takaharu, Kato Reiko, Saeki Kazuko, Nonami Atsushi, Sasaki Mika, Kuriyama Masamitsu, Saito Naoaki, Shibuya Masabumi, Yoshimura Akihiko

Abstract excerpt

The signalling cascade including Raf, mitogen-activated protein kinase (MAPK) kinase and extracellular-signal-regulated kinase (ERK) is important in many facets of cellular regulation. Raf is activated through both Ras-dependent and Ras-independent mechanisms, but the regulatory mechanisms of Raf activation remain unclear. Two families of membrane-bound molecules, Sprouty and Sprouty-related...

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Identifiers

PMID: 12717443
DOI: 10.1038/ncb978

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.PMID 12717443Read ↗

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