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Article

Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.

Cancer research - 1 Sept 2009

Brady Suzanne C, Coleman Mathew L, Munro June, Feller Stephan M, Morrice Nicolas A, Olson Michael F

Abstract excerpt

Sprouty2 is a feedback regulator that controls the Ras/Raf/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase (MAPK) pathway at multiple levels, one way being through direct interaction with Raf kinases. Consistent with a role as a tumor suppressor, Sprouty2 expression is often down-regulated in human cancers. However, Sprouty2 is up-regulated in some cancers, suggesting the existence of...

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Enzyme Activation
Intracellular Signaling Peptides and Proteins
MAP Kinase Signaling System
Neoplasms
NIH 3T3 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Protein Conformation

Proto-Oncogene Proteins B-raf

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Identifiers

PMID: 19690147
DOI: 10.1158/0008-5472.CAN-08-4447
PMCID: PMC2762204

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