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Article

Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.

The international journal of biochemistry & cell biology - 1 May 2012

Meng Songshu, Zhang Miao, Pan Wenyan, Li Zhongliang, Anderson Deborah H, Zhang Shengping, Ge Baoxue, Wang Chuangui

Abstract excerpt

Sprouty-related EVH1 domain (Spred) proteins modulate growth factor receptor signaling by inhibiting the Ras/ERK pathway. In particular, the Sprouty-related domain (SPR) of Spred2 is essential for the Spred2-mediated inhibitory effect, but the molecular mechanism is largely unknown. We show here...

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Source

Identifiers

PMID: 22305891
DOI: 10.1016/j.biocel.2012.01.014

Genes

SPR
EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22305891-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.PMID 22305891Read ↗

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