Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of the receptor FGFRL1 with the negative regulator Spred1.

Cellular signalling - 1 Sept 2011

Zhuang Lei, Villiger Peter, Trueb Beat

Abstract excerpt

FGFRL1 is a member of the fibroblast growth factor receptor family. It plays an essential role during branching morphogenesis of the metanephric kidneys, as mice with a targeted deletion of the Fgfrl1 gene show severe kidney dysplasia. Here we used the yeast two-hybrid system to demonstrate that FGFRL1 binds with its C-terminal, histidine-rich domain to Spred1 and to other proteins of the Sprouty/Spred family....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Chlorocebus aethiops
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COS Cells

Share to Golgi Apparatus

Share to Intracellular Signaling Peptides and Proteins

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 21616146
DOI: 10.1016/j.cellsig.2011.05.006

Genes

FGFRL1
FGF3
FGF8
SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of the receptor FGFRL1 with the negative regulator Spred1.PMID 21616146Read ↗

The Sprouty/Spred family as tumor suppressors: Coming of ageSemantic proximity Read ↗

SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling.Semantic proximity Read ↗

Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.Semantic proximity Read ↗

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.Semantic proximity Read ↗

Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.Semantic proximity Read ↗

Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype.Semantic proximity Read ↗

Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling.Semantic proximity Read ↗

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.Semantic proximity Read ↗

Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.Semantic proximity Read ↗

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.Semantic proximity Read ↗

Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction.Semantic proximity Read ↗

A Sprouty4 Mutation Identified in Kallmann Syndrome Increases the Inhibitory Potency of the Protein towards FGF and Connected Processes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.