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Article

Contribution of individual histidines to the global stability of human prolactin.

Protein science : a publication of the Protein Society - 1 May 2009

Keeler Camille, Tettamanzi M Cristina, Meshack Syrus, Hodsdon Michael E

Abstract excerpt

A member of the family of hematopoietic cytokines human prolactin (hPRL) is a 23k kDa polypeptide hormone, which displays pH dependence in its structural and functional properties. The binding affinity of hPRL for the extracellular domain of its receptor decreases 500-fold over the relatively narrow, physiologic pH range from 8 to 6; whereas, the affinity of human growth hormone (hGH), its closest evolutionary...

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Identifiers

PMID: 19384991
DOI: 10.1002/pro.100
PMCID: PMC2771294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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