Article
A genomewide screen for tolerance to cationic drugs reveals genes important for potassium homeostasis in Saccharomyces cerevisiae.
Eukaryotic cell - 1 Sept 2011
Barreto Lina, Canadell David, Petrezsélyová Silvia, Navarrete Clara, Maresová Lydie, Peréz-Valle Jorge, Herrera Rito, Olier Iván, Giraldo Jesús, Sychrová Hana, Yenush Lynne, Ramos José, Ariño Joaquín
Abstract excerpt
Potassium homeostasis is crucial for living cells. In the yeast Saccharomyces cerevisiae, the uptake of potassium is driven by the electrochemical gradient generated by the Pma1 H(+)-ATPase, and this process represents a major consumer of the gradient. We considered that any mutation resulting in an alteration of the electrochemical gradient could give rise to anomalous sensitivity to any cationic drug...
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