Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional mitochondria are essential for Saccharomyces cerevisiae cellular resistance to bleomycin.

Current genetics - 1 Sept 1996

He C H, Masson J Y, Ramotar D

Abstract excerpt

The antitumor activity of bleomycin is associated with its ability to produce DNA lesions. The cellular process that repairs bleomycin-induced DNA lesions is not entirely clear. To understand how these DNA lesions are repaired in eukaryotic cells, we used mini Tn3 : : LEU2 :: LacZ transposon mutagenesis to isolate yeast mutants that were hypersensitive to bleomycin. One of the mutants, HCY69, was characterized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Transposable Elements
Share to Drug Resistance, Microbial
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Mutation

Share to Nuclear Proteins

Share to Phenotype

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 8781169
DOI: 10.1007/s002940050133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional mitochondria are essential for Saccharomyces cerevisiae cellular resistance to bleomycin.PMID 8781169Read ↗

A Saccharomyces cerevisiae mutant defines a new locus essential for resistance to the antitumour drug bleomycin.Semantic proximity Read ↗

Overexpression of genes involved in vesicular trafficking to the vacuole defends against lethal effects of oxidative damage.Semantic proximity Read ↗

An allele of the yeast RPB7 gene, encoding an essential subunit of RNA polymerase II, reduces cellular resistance to the antitumor drug bleomycin.Semantic proximity Read ↗

Disruption of the Saccharomyces cerevisiae cell-wall pathway gene SLG1 causes hypersensitivity to the antitumor drug bleomycin.Semantic proximity Read ↗

Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells.Semantic proximity Read ↗

The pso mutants of Saccharomyces cerevisiae comprise two groups: one deficient in DNA repair and another with altered mutagen metabolism.Semantic proximity Read ↗

pHAZE: a shuttle vector system for the detection and analysis of ionizing radiation-induced mutations.Semantic proximity Read ↗

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.Semantic proximity Read ↗

A genome-wide screen in Saccharomyces cerevisiae reveals altered transport as a mechanism of resistance to the anticancer drug bleomycin.Semantic proximity Read ↗

Heme deficiency sensitizes yeast cells to oxidative stress induced by hydroxyurea.Semantic proximity Read ↗

A functional genomics approach to identify and characterize oxidation resistance genes.Semantic proximity Read ↗

Genetic manipulation of yeast to identify genes involved in regulation of chemosensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.