Article
In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging.
Mechanisms of ageing and development - 1 Apr 2003
Olivieri Fabiola, Bonafè Massimiliano, Giovagnetti Simona, Stecconi Rosalia, Cardelli Maurizio, Cavallone Luca, Spazzafumo Liana, Marchegiani Francesca, Carrieri Giuseppina, Mugianesi Elena, Giampieri Claudia, Centurelli Matteo, Moresi Raffaella, Tesei Silvia, Lisa Rosamaria, Viticchi Claudio, Falsetti Lorenzo, Salvioli Stefano, Franceschi Claudio
Abstract excerpt
In the present investigation we analysed Interleukin 6 (IL-6) in vitro production by Epstein-Barr virus (EBV)-immortalized B lymphocytes established from 43 subjects, 15 young people and 28 elderly people, including 18 centenarians, after 3, 6, 9, 24, 48 and 72 h of culture. The subjects were genotypized for the C to G transition at nucleotide -174 of IL-6 gene promoter (-174 C/G) and were classified as C allele...
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