Article
Genetic predisposition to higher production of interleukin-6 through -174 G > C polymorphism predicts global cognitive decline in oldest-old with cognitive impairment no dementia.
Arquivos de neuro-psiquiatria - 1 Nov 2015
Fraga Vanessa G, Guimarães Henrique C, Teixeira Antônio L, Barbosa Maira T, Mateo Elvis C C, Carvalho Maria G, Caramelli Paulo, Gomes Karina B
Abstract excerpt
Interleukin 6 (IL-6) is a pro-inflammatory cytokine upregulated in neurodegenerative contexts. The polymorphism IL-6 -174 G > C influences release levels of this cytokine. We aimed to evaluate the influence of IL-6 -174 G > C on global cognitive score of a group with cognitive impairment no dementia in one year of follow-up.Methods The subjects were categorized in two groups: short-term decline in global...
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