Article
The -174 C/G locus affects in vitro/in vivo IL-6 production during aging.
Experimental gerontology - 1 Jan 2000
Olivieri Fabiola, Bonafè Massimiliano, Cavallone Luca, Giovagnetti Simona, Marchegiani Francesca, Cardelli Maurizio, Mugianesi Elena, Giampieri Claudia, Moresi Raffaella, Stecconi Rosalia, Lisa Rosamaria, Franceschi Claudio
Abstract excerpt
IL-6 in vitro production, as well as the serum/plasma concentration of the cytokine, increase with age. In the present investigation, a total of 62 individuals (31 males and 31 females), aged from 29 to 93 years of age (mean age of males: 60.4 years; mean age of females: 59.4 years) were assessed for IL-6 plasma concentration, and for IL-6 in vitro production, using supernatants of 4h cultured adherent peripheral...
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