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Article

The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults.

European cytokine network - 1 Mar 2001

Kilpinen S, Hulkkonen J, Wang X Y, Hurme M

Abstract excerpt

In the promoter region of the IL-6 gene there is a single base exchange (G --> C) polymorphism at position -174. Recent findings suggest that this polymorphism may affect the transcription rate of the IL-6 gene and IL-6 plasma levels. To analyse its biological significance, we examined IL-6 plasma levels in cord blood and IL-6 production by neonatal cells after LPS-stimulation in relation to the presence of the...

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PMID: 11282548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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