Article

DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1

2023-10-06

Abstract excerpt

The circadian-controlled DNA repair exhibits a strong diurnal rhythm. Disruption in circadian clock and DNA repair is closely linked with hepatocellular carcinoma (HCC) progression, but the mechanism remains unknown. Here, we show that polymerase beta (Polb), a critical enzyme in the DNA base excision repair pathway, is rhythmically expressed at the translational level in mouse livers. Hepatic Polb dysfunction dam...

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Literature Corpus work: b278e3cc-2b78-576e-94f2-1c97b8b779ec
DOI: 10.21203/rs.3.rs-3350322/v1

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