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Article

The mechanism of cytokeratin aggresome formation: the role of mutant ubiquitin (UBB+1).

Experimental and molecular pathology - 1 Apr 2003

Bardag-Gorce F, Riley N, Nguyen V, Montgomery R O, French B A, Li J, van Leeuwen F W, Lungo W, McPhaul L W, French S W

Abstract excerpt

Aggresome formation in cells involves the failure of the ubiquitin-proteasome pathway to dispose of proteins destined for degradation by the 26S proteasome. UBB(+1) is present in Mallory bodies in alcoholic liver disease and in aggresomes formed in Alzheimer's desease. The present investigation focuses on the role that UBB(+1) plays in cytokeratin aggresome formation in Mallory bodies (MBs) in vitro....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12710947
DOI: 10.1016/s0014-4800(02)00024-2

Genes

UBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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