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Article

Expression of a mutant ER-retained polytope membrane protein in cultured rat hepatocytes results in Mallory body formation.

Histochemistry and cell biology - 1 Jan 2002

Hirano Kiyoko, Roth Jürgen, Zuber Christian, Ziak Martin

Abstract excerpt

Mallory bodies represent cytokeratin-rich inclusion bodies which occur characteristically but not exclusively in human alcoholic liver disease and experimentally in mice during chronic intoxication with drugs. We report the first in vitro cell system of Mallory body induction. In clone 9 rat hepatocytes stably transfected to express an ER-retained T126M-aquaporin-2 (AQP2), on the mean 40% of the cells contained...

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Identifiers

PMID: 11819096
DOI: 10.1007/s00418-001-0370-2

Genes

AQP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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