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Article

HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2018

Guilbert Solenn M, Lambert Herman, Rodrigue Marc-Antoine, Fuchs Margit, Landry Jacques, Lavoie Josée N

Abstract excerpt

BCL2-associated athanogene (BAG)-3 is viewed as a platform that would physically and functionally link distinct classes of molecular chaperones of the heat shock protein (HSP) family for the stabilization and clearance of damaged proteins. In this study, we show that HSPB8, a member of the small heat shock protein subfamily, cooperates with BAG3 to coordinate the sequestration of harmful proteins and the cellular...

Read the complete abstract on PubMed

Topics

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Share to Apoptosis Regulatory Proteins
Share to Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kelch-Like ECH-Associated Protein 1

Share to Molecular Chaperones

Share to NF-E2-Related Factor 2

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Source

Identifiers

PMID: 29405094
DOI: 10.1096/fj.201700558RR

Genes

BAG3
HSPB8
SQSTM1
BCL2
KEAP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency.PMID 29405094Read ↗

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