Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered dynamics of ubiquitin hybrid proteins during tumor cell apoptosis.

Cell death & disease - 19 Jan 2012

Han X-J, Lee M-J, Yu G-R, Lee Z-W, Bae J-Y, Bae Y-C, Kang S-H, Kim D-G

Abstract excerpt

The ubiquitin hybrid genes Uba80 and Uba52 encode ubiquitin (Ub), which is fused to the ribosomal proteins S27a (RPS27a) and L40 (RPL40), respectively. Here, we show that these genes are preferentially over-expressed during hepatoma cell apoptosis. Experiments using the tet-inducible transgenic system revealed that over-expression of the ubiquitin hybrid genes sensitized the cells to apoptosis. Further analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to In Situ Nick-End Labeling
Share to Lentivirus
Share to Luciferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutant Chimeric Proteins

Share to Ribosomal Proteins

Share to Transduction, Genetic

Share to Ubiquitination

Share to Ubiquitins

Source

Open in PubMed Open full text

Identifiers

PMID: 22258406
DOI: 10.1038/cddis.2011.142
PMCID: PMC3270276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Altered dynamics of ubiquitin hybrid proteins during tumor cell apoptosis.PMID 22258406Read ↗

Endoplasmic reticulum stress-induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis.Semantic proximity Read ↗

Heat shock protein 20 (HSPB6) regulates apoptosis in human hepatocellular carcinoma cells: Direct association with BaxSemantic proximity Read ↗

Analysis of ubiquitination in vivo using a transgenic mouse model.Semantic proximity Read ↗

Involvement of polyubiquitin chains via specific chain linkages in stress response in mammalian cells.Semantic proximity Read ↗

The mechanism of cytokeratin aggresome formation: the role of mutant ubiquitin (UBB+1).Semantic proximity Read ↗

Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes.Semantic proximity Read ↗

The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents.Semantic proximity Read ↗

Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic MiceSemantic proximity Read ↗

Hepatic expression of SV40 small-T antigen blocks the in vivo CD95-mediated apoptosis.Semantic proximity Read ↗

Proteasomal insensitivity of apoptin in tumor cells.Semantic proximity Read ↗

Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.