Article
Molecular misreading of the ubiquitin B gene and hepatic mallory body formation.
Gastroenterology - 1 Jun 2002
McPhaul Laron W, Wang Jun, Hol Elly M, Sonnemans Marc A F, Riley Nora, Nguyen Victoria, Yuan Qi Xiao, Lue Yan-He, Van Leeuwen Fred W, French Samuel W
Abstract excerpt
BACKGROUND & AIMS: Molecular misreading of the ubiquitin B gene has been documented in the cerebral cortex of patients with Alzheimer's disease and Down syndrome. This novel process consists of the unfaithful conversion of genomic information into aberrant transcripts and its subsequent translation into +1 proteins. METHODS: Because Mallory bodies (MBs) also contain ubiquitinated proteins, we stained 11 autopsied...
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