Article
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.
Science (New York, N.Y.) - 29 Oct 1999
Mayer T U, Kapoor T M, Haggarty S J, King R W, Schreiber S L, Mitchison T J
Abstract excerpt
Small molecules that perturb specific protein functions are valuable tools for dissecting complex processes in mammalian cells. A combination of two phenotype-based screens, one based on a specific posttranslational modification, the other visualizing microtubules and chromatin, was used to identify compounds that affect mitosis. One compound, here named monastrol, arrested mammalian cells in mitosis with...
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