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Article

Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea.

Development (Cambridge, England) - 1 Jun 2003

Dabdoub Alain, Donohue Maura J, Brennan Angela, Wolf Vladimir, Montcouquiol Mireille, Sassoon David A, Hseih Jen-Chih, Rubin Jeffrey S, Salinas Patricia C, Kelley Matthew W

Abstract excerpt

In the mammalian cochlea, stereociliary bundles located on mechanosensory hair cells within the sensory epithelium are unidirectionally oriented. Development of this planar polarity is necessary for normal hearing as stereociliary bundles are only sensitive to vibrations in a single plane; however, the mechanisms governing their orientation are unknown. We report that Wnt signaling regulates the development of...

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Identifiers

PMID: 12702652
DOI: 10.1242/dev.00448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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