Article
Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.
Development (Cambridge, England) - 1 Oct 2014
Hua Zhong L, Chang Hao, Wang Yanshu, Smallwood Philip M, Nathans Jeremy
Abstract excerpt
In mammals, a set of anatomically diverse polarity processes - including axon growth and guidance, hair follicle orientation, and stereociliary bundle orientation in inner ear sensory hair cells - appear to be mechanistically related, as judged by their dependence on vertebrate homologues of core tissue polarity/planar cell polarity (PCP) genes in Drosophila. To explore more deeply the mechanistic similarities...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Axons
- Brain
- Cell Polarity
- Cell Proliferation
- Epithelial Cells
- Frizzled Receptors
- Hair Follicle
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Phenotype
- Phylogeny