Article
Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling.
Development (Cambridge, England) - 1 May 2026
Jarysta Amandine, Nemelka Justin, Ramanathan Muthumeena, Goodrich Ellison J, Vonderhaar Brianna L, Park Sungjin, Orlandi Cesare, Deans Michael R, Tarchini Basile
Abstract excerpt
Planar cell polarity (PCP) proteins, including Van Gogh-like and frizzled, orient sensory hair cells in the inner ear. Because most PCP mouse models die at birth, orientation defects have been studied mainly at fetal stages. Using viable conditional mutants lacking both Vangl1 and Vangl2, or Fzd3 and Fzd6, we show that misoriented auditory hair cells undergo extensive postnatal reorientation, largely correcting...
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