Article
Coupling planar cell polarity signaling to morphogenesis.
TheScientificWorldJournal - 15 Feb 2002
Axelrod Jeffrey D, McNeill Helen
Abstract excerpt
Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical-basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymmetry. Most of what...
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