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Article

Bile salt export pump (BSEP/ABCB11): trafficking and sorting disturbances.

Current molecular pharmacology - 1 Jul 2013

Hayashi Hisamitsu, Sugiyama Yuichi

Abstract excerpt

Bile salt export pump (BSEP/ABCB11), a member of the family of ATP-binding cassette transporters, is localized on the canalicular membrane of hepatocytes and mediates the efficient biliary excretion of bile acid. The secretion of bile acid into bile by BSEP provides the primary osmotic driving force for bile flow generation. Intrahepatic cholestasis resulting from dysfunction of BSEP can be caused by a mutation...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 11
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23876151
DOI: 10.2174/18744672113069990036

Genes

ABCB11

Provenance

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