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Article

4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps.

Hepatology (Baltimore, Md.) - 1 Jun 2007

Hayashi Hisamitsu, Sugiyama Yuichi

Abstract excerpt

UNLABELLED: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is caused by a mutation in the bile salt export pump (BSEP/ABCB11) gene. We previously reported that E297G and D482G BSEP, which are frequently found mutations in European patients, result in impaired membrane trafficking, w...

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Source

Identifiers

PMID: 17538928
DOI: 10.1002/hep.21630

Genes

ABCB11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17538928-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps.PMID 17538928Read ↗

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Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11.Semantic proximity Read ↗

Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2.Semantic proximity Read ↗

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Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function.Semantic proximity Read ↗

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