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Article

Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells.

Journal of gastroenterology - 1 May 2014

Kagawa Tatehiro, Orii Reiko, Hirose Shunji, Arase Yoshitaka, Shiraishi Koichi, Mizutani Akiko, Tsukamoto Hidekazu, Mine Tetsuya

Abstract excerpt

BACKGROUND: Ursodeoxycholic acid (UDCA) partly exerts choleretic effects by modifying the function of the bile salt export pump (Bsep, ABCB11). UDCA induces insertion of Bsep into the canalicular membrane of hepatocytes; however, underlying mechanisms remain unknown. We aimed to elucidate molecular mechanisms behind UDCA-induced Bsep activation. METHODS: We established MDCK II cells stably expressing both Bsep...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 11
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23722250
DOI: 10.1007/s00535-013-0833-y

Genes

ABCB11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells.PMID 23722250Read ↗

Bile salt export pump (BSEP/ABCB11): trafficking and sorting disturbances.Semantic proximity Read ↗

Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11).Semantic proximity Read ↗

Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function.Semantic proximity Read ↗

The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation.Semantic proximity Read ↗

Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Semantic proximity Read ↗

4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps.Semantic proximity Read ↗

The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease.Semantic proximity Read ↗

Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells.Semantic proximity Read ↗

Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells.Semantic proximity Read ↗

Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations.Semantic proximity Read ↗

Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2.Semantic proximity Read ↗

The bile salt export pump (BSEP) in health and diseaseSemantic proximity Read ↗

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