Article
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice.
The Journal of biological chemistry - 21 May 2004
Assem Mahfoud, Schuetz Erin G, Leggas Markos, Sun Daxi, Yasuda Kazuto, Reid Glen, Zelcer Noam, Adachi Masashi, Strom Stephen, Evans Ronald M, Moore David D, Borst Piet, Schuetz John D
Abstract excerpt
The ABC transporter, Mrp4, transports the sulfated steroid DHEA-s, and sulfated bile acids interact with Mrp4 with high affinity. Hepatic Mrp4 levels are low, but increase under cholestatic conditions. We therefore inferred that up-regulation of Mrp4 during cholestasis is a compensatory mechanism to protect the liver from accumulation of hydrophobic bile acids. We determined that the nuclear receptor CAR is...
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