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The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis.

FEMS yeast research - 1 Mar 2002

Kamińska Joanna, Grabińska Kariona, Kwapisz Marta, Sikora Jacek, Smagowicz Wieslaw J, Palamarczyk Grazyna, Zoładek Teresa, Boguta Magdalena

Abstract excerpt

tRNA isopentenylation is a branch of an isoprenoid pathway in yeast. There is a competition for a substrate between isoprenoid biosynthetic enzyme Erg20p and tRNA isopentenyltransferase. Here we studied the direct effect of elevated tRNA biosynthesis on ERG20 expression. The maf1-1 mutant of Saccharomyces cerevisiae that has enhanced cellular tRNA levels was used. We show that both ERG20 transcript and Erg20...

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PMID: 12702319
DOI: 10.1111/j.1567-1364.2002.tb00066.x

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