Article
Mutations in yeast mt tRNAs: specific and general suppression by nuclear encoded tRNA interactors.
Gene - 1 Aug 2006
De Luca C, Besagni C, Frontali L, Bolotin-Fukuhara M, Francisci S
Abstract excerpt
Mutations in mitochondrial tRNA genes can produce alterations in tRNA structure resulting in defective mitochondrial protein synthesis and hence respiratory defects. Such defects are often at the origin of neurodegenerative diseases in humans and can be easily studied in yeast since respiratory deficient mutants are viable. Several nuclear encoded tRNA interactors have been shown to rescue the mitochondrial...
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