Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Competition between a sterol biosynthetic enzyme and tRNA modification in addition to changes in the protein synthesis machinery causes altered nonsense suppression.

Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2000

Benko A L, Vaduva G, Martin N C, Hopper A K

Abstract excerpt

The Saccharomyces cerevisiae Mod5 protein catalyzes isopentenylation of A to i(6)A on tRNAs in the nucleus, cytosol, and mitochondria. The substrate for Mod5p, dimethylallyl pyrophosphate, is also a substrate for Erg20p that catalyzes an essential step in sterol biosynthesis. Changing the distribution of Mod5p so that less Mod5p is present in the cytosol decreases i(6)A on cytosolic tRNAs and alters tRNA-mediated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkyl and Aryl Transferases
Share to Codon, Nonsense

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Hemiterpenes

Share to Organophosphorus Compounds

Share to RNA, Transfer

Share to Sterols

Share to Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 10618371
DOI: 10.1073/pnas.97.1.61
PMCID: PMC26616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Competition between a sterol biosynthetic enzyme and tRNA modification in addition to changes in the protein synthesis machinery causes altered nonsense suppression.PMID 10618371Read ↗

RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification.Semantic proximity Read ↗

maf1 mutation alters the subcellular localization of the Mod5 protein in yeast.Semantic proximity Read ↗

New reporters for monitoring cellular NMD.Semantic proximity Read ↗

Genetic interactions of yeast eukaryotic translation initiation factor 5A (eIF5A) reveal connections to poly(A)-binding protein and protein kinase C signaling.Semantic proximity Read ↗

Suppressor Mutagenesis Identifies a Velvet Complex Remediator of Aspergillus nidulans Secondary MetabolismSemantic proximity Read ↗

The yeast magmas ortholog pam16 has an essential function in fermentative growth that involves sphingolipid metabolism.Semantic proximity Read ↗

The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases.Semantic proximity Read ↗

Phenotypic consequences of purine nucleotide imbalance in Saccharomyces cerevisiae.Semantic proximity Read ↗

The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis.Semantic proximity Read ↗

tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p.Semantic proximity Read ↗

Protein Phosphatase Sit4 Affects Lipid Droplet Synthesis and Soraphen A Resistance Independent of Its Role in Regulating Elongator Dependent tRNA Modification.Semantic proximity Read ↗

Guanine nucleotide pool imbalance impairs multiple steps of protein synthesis and disrupts GCN4 translational control in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.