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Article

ATM alterations in childhood non-Hodgkin lymphoma.

Cancer genetics and cytogenetics - 15 Apr 2006

Gumy-Pause Fabienne, Wacker Pierre, Maillet Philippe, Betts David R, Sappino André-Pascal

Abstract excerpt

ATM gene alterations and impaired ATM protein expression have been described in various adult lymphoproliferative malignancies, suggesting that ATM contributes to lymphomagenesis. The present study investigated the prevalence of ATM gene and ATM protein expression alterations in sporadic childhood non-Hodgkin lymphoma (NHL). Twenty-seven cases of NHL were screened for ATM mutations by denaturing high-performance...

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Source

Identifiers

PMID: 16631465
DOI: 10.1016/j.cancergencyto.2005.09.005

Genes

ATM

Provenance

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ATM alterations in childhood non-Hodgkin lymphoma.PMID 16631465Read ↗

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Mantle cell lymphoma is characterized by inactivation of the ATM gene.Semantic proximity Read ↗

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ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele.Semantic proximity Read ↗

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