Hepatocyte Nuclear Factor 4α Isoforms Originated from the P1 Promoter Are Expressed in Human Pancreatic β-Cells and Exhibit Stronger Transcriptional Potentials than P2 Promoter-Driven Isoforms

Abstract excerpt

The nuclear receptor hepatocyte nuclear factor (HNF) 4 alpha is involved in a transcriptional network and plays an important role in pancreatic beta-cells. Mutations in the HNF4 alpha gene are correlated with maturity-onset diabetes of the young 1. HNF4 alpha isoforms result from both alternative splicing and alternate usage of promoters P1 and P2. It has recently been reported that HNF4 alpha transcription is...

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