Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4α.

doi:10.1002/jcb.27407

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Article

Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4α.

Journal of cellular biochemistry - 1 Jan 2019

Guo Shangdong, Lu Hong

Abstract excerpt

Hepatocyte nuclear factor 4α (HNF4α) is a master regulator of development and function of digestive tissues. The HNF4A gene uses two separate promoters P1 and P2, with P1 products predominant in adult liver, whereas P2 products prevalent in fetal liver, pancreas, and liver/colon cancer. To date, the mechanisms for the regulation of HNF4A and the dynamic switch of P1-HNF4α and P2-HNF4α during ontogenesis and...

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Identifiers

PMID: 30191603
DOI: 10.1002/jcb.27407
PMCID: PMC7745837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.