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Article

A transcription factor regulatory circuit in differentiated pancreatic cells.

Proceedings of the National Academy of Sciences of the United States of America - 4 Dec 2001

Boj S F, Parrizas M, Maestro M A, Ferrer J

Abstract excerpt

Mutations in the human genes encoding hepatocyte nuclear factors (HNF) 1alpha, 1beta, 4alpha, and IPF1(PDX1/IDX1/STF1) result in pancreatic beta cell dysfunction and diabetes mellitus. In hepatocytes, hnf4alpha controls the transcription of hnf1alpha, suggesting that this same interaction may operate in beta cells and thus account for the common diabetic phenotype. We show that, in pancreatic islet and exocrine...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Hepatocyte Nuclear Factor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11717395
DOI: 10.1073/pnas.241349398
PMCID: PMC64707

Genes

PDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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