Article

Human Hepatocyte Nuclear Factor 4-α encodes isoforms with distinct transcriptional functions

2019-03-21

Abstract excerpt

<h4>SUMMARY</h4> HNF4α is a nuclear receptor produced as 12 isoforms from two promoters by alternative splicing. In order to characterize the transcriptional capacities of all 12 HNF4α isoforms, stable lines expressing each isoform were generated. The entire transcriptome associated with each isoform was analyzed as well as their respective interacting proteome. Major differences were noted in the transcriptional...

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Literature Corpus work: 36ebcd52-4e89-5f8b-abf3-e5ad68dff77b
DOI: 10.1101/585604

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