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Article

Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.

The Journal of clinical investigation - 1 Sept 2002

Hansen Sara K, Párrizas Marcelina, Jensen Maria L, Pruhova Stepanka, Ek Jakob, Boj Sylvia F, Johansen Anders, Maestro Miguel A, Rivera Francisca, Eiberg Hans, Andel Michal, Lebl Jan, Pedersen Oluf, Ferrer Jorge, Hansen Torben

Abstract excerpt

Mutations in the genes encoding hepatocyte nuclear factor 4alpha (HNF-4alpha) and HNF-1alpha impair insulin secretion and cause maturity onset diabetes of the young (MODY). HNF-4alpha is known to be an essential positive regulator of HNF-1alpha. More recent data demonstrates that HNF-4alpha expression is dependent on HNF-1alpha in mouse pancreatic islets and exocrine cells. This effect is mediated by binding of...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Hepatocyte Nuclear Factor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12235114
DOI: 10.1172/JCI15085
PMCID: PMC151122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.PMID 12235114Read ↗

Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell functionSemantic proximity Read ↗

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A transcription factor regulatory circuit in differentiated pancreatic cells.Semantic proximity Read ↗

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.Semantic proximity Read ↗

HNF-4alpha: from MODY to late-onset type 2 diabetes.Semantic proximity Read ↗

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism.Semantic proximity Read ↗

Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4α.Semantic proximity Read ↗

A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.Semantic proximity Read ↗

Roles of HNF1α and HNF4α in pancreatic β-cells: lessons from a monogenic form of diabetes (MODY).Semantic proximity Read ↗

Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degreeSemantic proximity Read ↗

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