Article

Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

2002-09-15

Abstract excerpt

Mutations in the genes encoding hepatocyte nuclear factor 4 (HNF-4) and HNF-1 impair insulin secretion and cause maturity onset diabetes of the young (MODY). HNF-4 is known to be an essential positive regulator of HNF-1. More recent data demonstrates that HNF-4 expression is dependent on HNF-1 in mouse pancreatic islets and exocrine cells. This effect is mediated by binding of HNF-1 to a tissue-specific promoter (...

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Literature Corpus work: a4b95010-eada-5875-ace9-0ecaa4cfac55
DOI: 10.1172/jci0215085

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