Article
Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 16 Feb 1999
McDonald F J, Yang B, Hrstka R F, Drummond H A, Tarr D E, McCray P B, Stokes J B, Welsh M J, Williamson R A
Abstract excerpt
The epithelial Na+ channel (ENaC) is composed of three homologous subunits: alpha, beta and gamma. We used gene targeting to disrupt the beta subunit gene of ENaC in mice. The betaENaC-deficient mice showed normal prenatal development but died within 2 days after birth, most likely of hyperkalemia. In the -/- mice, we found an increased urine Na+ concentration despite hyponatremia and a decreased urine K+...
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