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Article

Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.

The Journal of biological chemistry - 27 Jun 2003

Morelli Laura, Llovera Ramiro, Gonzalez Silvia A, Affranchino Jose L, Prelli Frances, Frangione Blas, Ghiso Jorge, Castano Eduardo M

Abstract excerpt

Inherited amino acid substitutions at position 21, 22, or 23 of amyloid beta (Abeta) lead to presenile dementia or stroke. Insulin-degrading enzyme (IDE) can hydrolyze Abeta wild type, yet whether IDE is capable of degrading Abeta bearing pathogenic substitutions is not known. We studied the degradation of all of the published Abeta genetic variants by recombinant rat IDE (rIDE). Monomeric Abeta wild type,...

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Identifiers

PMID: 12695513
DOI: 10.1074/jbc.M300276200

Genes

IDE
SDS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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