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Article

Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.

Neurobiology of disease - 1 Sept 2008

Betts Vicki, Leissring Malcolm A, Dolios Georgia, Wang Rong, Selkoe Dennis J, Walsh Dominic M

Abstract excerpt

Five point mutations within the amyloid beta-protein (Abeta) sequence of the APP gene are associated with hereditary diseases which are similar or identical to Alzheimer's disease and encode: the A21G (Flemish), E22G (Arctic), E22K (Italian), E22Q (Dutch) and the D23N (Iowa) amino acid substitutions. Although a substantial body of data exists on the effects of these mutations on Abeta production, whether or not...

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Source

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Identifiers

PMID: 18602473
DOI: 10.1016/j.nbd.2008.06.001
PMCID: PMC3160758

Genes

IDE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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