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Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia.

Biochemical and biophysical research communications - 8 Jul 2005

Morelli Laura, Llovera Ramiro E, Alonso Leonardo G, Frangione Blas, de Prat-Gay Gonzalo, Ghiso Jorge, Castaño Eduardo M

Abstract excerpt

Familial British dementia (FBD) and familial Danish dementia (FDD) are autosomal dominant disorders characterized by cerebrovascular and parenchymal amyloid deposition and neurofibrillary degeneration. In both conditions, the genetic defects cause the loss of the normal stop codon in the precurso...

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PMID: 15913558
DOI: 10.1016/j.bbrc.2005.05.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15913558-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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