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Article

Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits.

The American journal of pathology - 1 Apr 2010

Tomidokoro Yasushi, Rostagno Agueda, Neubert Thomas A, Lu Yun, Rebeck G William, Frangione Blas, Greenberg Steven M, Ghiso Jorge

Abstract excerpt

Mutations within the amyloid-beta (Abeta) sequence, especially those clustered at residues 21-23, which are linked to early onset familial Alzheimer's disease (AD), are primarily associated with cerebral amyloid angiopathy (CAA). The basis for this predominant vascular amyloid burden and the differential clinical phenotypes of cerebral hemorrhage/stroke in some patients and dementia in others remain unknown. The...

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Identifiers

PMID: 20228223
DOI: 10.2353/ajpath.2010.090636
PMCID: PMC2843474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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