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Article

Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.

The Journal of biological chemistry - 31 Dec 2004

Morelli Laura, Llovera Ramiro E, Mathov Irina, Lue Lih-Fen, Frangione Blas, Ghiso Jorge, Castaño Eduardo M

Abstract excerpt

The accumulation of amyloid beta (Abeta) in the walls of small vessels in the cerebral cortex is associated with diseases characterized by dementia or stroke. These include Alzheimer's disease, Down syndrome, and sporadic and hereditary cerebral amyloid angiopathies (CAAs) related to mutations wi...

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PMID: 15489232
DOI: 10.1074/jbc.M407283200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15489232-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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