Article
Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome.
Tissue antigens - 1 Feb 2003
Quelvennec E, Bera O, Cabre P, Alizadeh M, Smadja D, Jugde F, Edan G, Semana G
Abstract excerpt
Among candidate genes involved in multiple sclerosis (MS) genetic susceptibility, MHC genes and particularly HLA-DRB1*1501-DQB1*0602 haplotype play a major role. Based on the strong linkage disequilibrium observed in Caucasians between DRB1*1501 and DQB1*0602 alleles, it is still impossible to dr...
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